From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited
نویسندگان
چکیده
منابع مشابه
the role of interleukin-23 in stability of in vitro t helper-17 cells.
interleukin (il)-17-producing t helper (th)-17 cells have recently been explained as a distinct population of cd4+ t cells which play an important role in immunity against infectious agents. establishment of persistent phenotype of th17 cells and recognition of lineage-deviating factors are of most attractive goals in modern researches in immunology. although il-6 and tgf-β are freque...
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The third lineage of T helper subsets, Th17, has recently been identified as an IL- 17-producing CD4+ Th cell, and its functions and regulatory mechanisms have been extensively characterized in immune responses. Functional studies have provided evidence that Th17 cells are important for the modulation of autoimmune responses, such as chronic asthma, rheumatoid arthritis, inflammatory bowel dise...
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CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literatur...
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Interleukin-17 (IL-17)-producing T helper cells (Th17 cells) constitute a lineage of CD4 effector T helper cells that is distinct from the Th1 and Th2 CD4 phenotypes. In humans, Th17 differentiation is induced in the presence of the cytokines IL-1 beta, IL-6 and TGF beta, whereas IL-23 maintains Th17 survival. Effector human Th17 cells express several cytokines and cell surface markers, includi...
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The immune system is designed to eradicate a large variety of invading pathogens with minimum immunopathology. T helper cells, also known as CD4+ T cells, may be subdivided into the T helper 1 (Th1) and the T helper 2 (Th2) subsets, which produce distinct profiles of cytokines [1,2]. These Th1 and Th2 cells have opposing roles, regulating immune responses to intracellular and extracellular path...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2008
ISSN: 0105-2896,1600-065X
DOI: 10.1111/j.1600-065x.2008.00714.x